Carcinoma Mucoepidermoide de Glándulas Salivales Intraoral: Factores Clínicos y Patológicos e Inmunoexpresión de c-erbB-2 en 29 Casos. Vanessa Fátima. Abstract. AVILA, Rodolfo Esteban et al. Mucoepidermoid Carcinoma of Salivary Glands: Histological and Inmunohistochemical Prognostic Factors. Publisher: El propósito de este estudio es presentar la casuística del carcinoma mucoepidermoide de glándulas salivales de pacientes diagnosticados en el.
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Sinonasal and maxillary tumors were not included in this study as intraoral salivary gland tumors since that in these locations mucoepidermoid carcinoma presents different origin rather than glandular Ellis et al. There is no consensus about the best antibody for the evaluation of c-erbB-2 irnmunoexpression Hanna et al. Mucoepidermoid carcinoma of the salivary glands: All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License.
Mucoepidermoid carcinoma of the mucoepidsrmoide glands clinical review of 42 cases.
A total of 16 cases were analyzed over a period of 18 years; males were Studies on intra-oral MEC have shown similar results with a higher percentage of low grade tumors Kokemueller et al. Head Neck, 26 4: There were no statistically significant differences for any analyzed variable affecting OS curves. Mucoepidermoid carcinoma of minor salivary glands: The clinicopathologic features and results of log rank tests for clinical variables are shown in tables 1 and 2respectively.
Am J Surg Pathol. Mucoepidermoid carcinoma of the salivary glands in Brazil: The palate was the most commonly affected site, with 21 cases Mucoepidermoid carcinoma of the salivary glands -clinical review of 42 cases.
Published works usually lose relevant survival information through time. Ann Otol Rhinol Laryngol.
Even though low-grade tumors did not develop metastases and high-grade tumors showed lower DFS rates after five years, no significant difference was found for the grading system or any of the evaluated prognostic factors. Intraoral mucoepidermoid carcinoma of salivary glands.
Previous studies of c-erbB-2 expression in salivary gland carcinomas are sparse, comprise heterogeneous subtypes, and show contradictory results Locati et al. Data regarding the positivity for c-erbB-2 on salivary gland tumors are very variable. Discrepancies were solved by consensus. MEC was prevalent in the female gender Mucoepidermoid carcinoma of intraoral salivary glands. Salivary glands ; ucoepidermoid carcinoma ; Prognostic factors.
Through a long follow-up period in present study was highlight the relevance of primary anatomical site, tumor size and metastasis as useful prognostic factors that may affect survival in patients with a primary diagnosis of head and neck mucoepidermoid carcinomas. Histological features and prognosis of patients with mucoepidermoid carcinoma of the parotid gland.
However, there are few articles with a significative number of cases Lopes et al. Mucoepidermoid tumors of the salivary glands. However, in the study of Lopes et al. All positive cases also expressed cytoplasmic staining.
Molecular differences in mucoepidermoid carcinoma and adenoid cystic carcinoma of the major salivary glands. There have been suggestions that the overexpression of c-erbB-2 on salivary gland tumors is related with histogenesis of these lesions Glisson et al.
This overexpression may be due to the process envolving histogenesis and celular differentiation. Data concerning survival glanfulas and metastasis were evaluated. The biological features and clinical behavior of mucoepidermoid carcinomas are widely variable and poorly understood. The three-level grading system commonly used by pathologists for MEC classification mainly considers the relative proportion of cell types epidermoid, intermediate and mucinous cellstheir respective degrees of atypia and growth patterns cystic, solid, or infiltrativetogether with neural and vascular invasion.
Due to the zalivales and diverse histology of these tumors, prognostic factors have been difficult to elucidate. Clinicopathologic and immunohistochemical study of intraoral mucoepidermoid carcinoma. However, many studies found that benign and malignant salivary gland neoplasms with evidence of myoepithelial lineage do not overexpress c-erbB-2 protein which support the view that this growth receptor is not involved in their pathogenesis Rosa et al.
There is a growing consensus that an aggressive surgical approach with adjuvant radiotherapy must always be considered for more advanced cases that present with a high histological grade, positive margins and cervical involvement.
Carcinoms follow-up period in this study ranged from 6 to months median 65 monthsand the 5 salivalds year OS rates were both Carcinoma of the parotid and submandibular glands a study of survival in patients.
Carcinoma mucoepidermoide de glándulas salivales en Brasil: relación clinicopatológica
In our series, patients demonstrated an earlier average age of occurrence, with a peak of incidence in the third and fourth decades of life, whereas previous studies described a prevalence in fifth and sixth decades of life Auclair et al.
How to cite this article. The c-erbB-2 oncoprotein is involved in glanduas degradation and proteolitic activity as well as in the increase in vessel permeability, endothelial cell growth, proliferation, migration, and differentiation Verbeek et al. However, its prognostic value should be validated with clinical studies and survival analyses. Through a long follow-up period in present study we could highlight the relevance of primary anatomical site, tumor size and metastasis as useful prognostic factors that may affect survival in patients with a primary diagnosis of head and neck mucoepidermoid carcinomas.
However, other studies reported a rare expression of c-erbB-2 on these tumors Kernohan et al.
The medical and surgical records mucoepidernoide all cases were reviewed for clinicopathological factors, such as age, gender, primary tumor location, tumor size, clinical stage, histological grade, treatment, compromised surgical margins, tumor recurrence, metastasis, disease-free survival DFS and overall survival OS.
Selecting antibodies to detect HER2 overexpression by immunohistochemistry in invasive mammary carcinomas. Further investigation of potential factors that may influence the survival of these patients should be encouraged through longer follow-up periods and larger samples.
In our series the results were similar with 21 Few papers evaluating only one type of oral salivary gland tumors are available. It is composed of mucous, epidermoid, intermediate, columnar and clear cells.