Rajeshkumar et al. World Journal of Pharmacy and Pharmaceutical Sciences. ANTICANCER ACTIVITY OF ANDROGRAPHIS PANICULATA. showing anticancer activity on HEp2 – Human larynx carcinoma cell lines in-vitro KEYWORDS: Andrographis paniculata,Herbal medicine. A refined extract of A. paniculata, also significantly reduces activities of lipid .. The anticancer activity was observed due to the presence of andrographolide.

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Cancer is the uncontrolled growth and division of cells and it leads to a mass of cells known as activit. So, here we are using the natural drugs from phytochemicals to reduce the toxicity level. Effect of silymarin on different acute inflammation models and on leukocyte migration. Phenols, polyphenols, flavonoids and their derivatives are ubiquitous in plants and have been found associated with the inhibition of atherosclerosis and cancer Cirla and Mann, It is assumed that the accumulation of these phytochemicals in A.

The effects of salinity levels on studied traits among the four accessions of A. Introduction Salinity is a major abiotic stress that causes important alterations in the plant growth and development.

Hepatoprotective and immunological effects of antioxidant drugs. In other words, under salinity stress, the tolerant accessions were capable of accumulating the higher amounts of proline, AG, and NAG than the sensitive accessions. Andrographis paniculata is an annual herb belongs to family Acanthaceae.

Hepatoprotective and antioxidant property of Andrographis paniculata Nees in BHC induced liver damage in mice. The heritability of proline was the highest 0. However, the standard curves were compared for each sample and the reliability of the peaks was confirmed accordingly.


These neutral organic compounds can also improve the inhibitory effects panicupata high ion concentrations on enzymatic activity without interfering with protein structure and function [ 35 ]. A pilot double blind study.

BioMed Research International

Indexed in Science Citation Index Expanded. Single-cell suspensions were prepared by the treatment of cells with 0. The materials were soaked for three days at room temperature. Generally, plants produce secondary metabolites in nature as defense mechanisms under different environmental stresses [ 27 ]. After 24 h, the cells were treated with the extracts.

The plants grown under salinity conditions performed different responses after four weeks of salt treatment. The process was repeated several times with the same solvent system until the solvent portion becomes colorless. View at Google Scholar K. Phytochemicals, such as flavonols and flavonoids were investigated to determine chemoprevention activity against cancer Conese and Blasi, Subscribe to Table of Contents Alerts.

Fundamentally, it can be concluded that if the production of anticancer phytochemicals of A. Our results indicated a positive correlation between the three anticancer phytochemicals and proline accumulation, which might be closely related to tolerance abilities indicated by physiological performances. As an aerial organ, leaves are directly exposed to various biotic and abiotic stresses, which demand metabolic adaptations for survival.

Therefore, the aim of this study was to determine the changes in the contents of the three main anticancer phytochemicals AG, NAG, and DDAG and their physiological implications in salt tolerance of A.

According to Talei et al.

Further studies are required to isolate the active constituents involved in the antioxidant and hepatoprotective activity of the plant. View at Google Scholar S. D and confirmed at Botany Department, Dr. Cancer is mainly studied by genetics and epigenetic modification. Journal of Pharmacology and Toxicology Volume 8 1: Recent studies have reported antitumor effects of the flavonoids, quercetin, genistein and baicalein obtained from plant extracts Shoeb et al.


These medicinal plant s possess good immunomodulatory and antioxidant properties, leading to anticancer activities. The plant extract contains three major groups of phytochemical compounds, namely, diterpenes, flavonoids and stigmasterols [ 16 ].

Analysis of the Anticancer Phytochemicals in Andrographis paniculata Nees. under Salinity Stress

Therefore, in the present study, an attempt was made to investigate the anticancer potential of hydroalcoholic extracts of A. The day seedlings were transferred from jiffy media into the pot with sand medium.

This is an open antocancer article distributed under the Creative Commons Attribution Licensewhich permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Phyto chemical analysis was performed to detect various compounds such as tannins, flavonoids, alkaloids, steroids etc. Likewise, panicuoata researchers suggested that proline and soluble flavonoids are involved in osmotic adjustment, protecting the cellular structures from oxidative damage and osmotic stress by accumulation in the vacuole, and so play an important role in increasing the oxidative stress tolerance through protecting the chloroplast and photosynthetic systems versus solar radiation by absorbing UV [ 2829 ].

The results obtained actibity the study indicate that A.

As in cancer cells the tumor suppressor genes E-cadherin and P shows the down regulation but while treating with the oc extract of Andrographis paniculata the genes show up-regulation.